Davis, L., Hanson, B., Gilliam, S., Pilot Study of the Effects of Mixed Light Touch Manual Therapies on Active Duty Soldiers with Chronic Post-Traumatic Stress Disorder and Injury to the Head, Journal of Bodywork & Movement Therapies (2016), 20, pp. 42-51. DOI: 10.1016/j.jbmt.2015.03.006
This pilot study was designed to examine the effects of mixed Light Touch Manual Therapies (LTMT) on headache, anxiety and other symptoms suffered by active duty United States service members experiencing chronic Post-Traumatic Stress Disorder (PTSD). Ten service members diagnosed with PTSD and having a self-reported injury to the head acquired at least two years prior, were provided with two hour-long sessions of mixed LTMT given a week apart. Data to assess the immediate and durable effects were gathered before and after the LTMT sessions. Results indicate that headache, anxiety, and pain interference were significantly reduced during the course of the pilot study. This suggests that mixed LTMT may be helpful in reducing some of the symptoms of PTSD and injury to the head. Further studies will be needed to determine if LTMT is an effective non-pharmacological treatment for headache, anxiety or other problems associated with PTSD or injury to the head.
United States service members (SM) who have deployed to Iraq and/or Afghanistan since September 11, 2001 are commonly impacted by problems such as battle injuries, chronic pain, mental health conditions, and impairments in social functioning (Spelman et al 2012). Among the most common problems afflicting deployed individuals are post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). PTSD was newly diagnosed in 103,000 individuals in all services between 2000-2012 (Fischer 2013). TBI was newly diagnosed in over 287,861 US military SM between 2000-2013 (Defense and Veterans Brain Injury Center 2014). TBI (Faul et al 2010) and PTSD (Kessler et al 2005) are prevalent in the civilian population as well and both PTSD and TBI are often comorbid in military and civilian populations (Stein & McAllister 2009).
One of the most common problems accompanying TBI is headache (Simons & Wolff 1946; Walker et al 2005), with estimates indicating that 30-90% of people sustaining a TBI go on to develop headaches (Lew et al 2006; Management of Concussion/mTBI Working Group 2009; Finkel et al 2012). Chronic posttraumatic headaches often become permanent (Lew et al 2006) and are considered to be one of the most disabling types of headaches (Theeler et al 2008, 2012). While headache is only one of many physical symptoms that may accompany TBI in military populations, it is the only problem that has been found to be significantly associated with mild TBI (mTBI) after statistically adjusting for PTSD and depression (Hoge et al 2008).
Headache pain from a TBI can significantly interfere with an individual’s quality of life for years (Ruff 2005; Channell et al 2009). Headache management options include a variety of medications but these are often accompanied by significant side effects (Goadsby et al 2002; Gallaher & Kunkel 2003) including an increase in headaches (Zwart et al 2003). Thus, identifying non-pharmacological headache management options is desirable. Some of these options include acupuncture (Melchart et al 2001; Vickers et al 2004), a variety of physical therapy techniques (Mills Roth 2003), biofeedback (Nestoriuc et al 2008) and massage therapy (Jensen et al 1990; Hernandez-Reif et al 1998; Lawler & Cameron 2006; Kennedy 2011). Several groups have reported that manual therapies requiring the application of a few hundred grams or less of pressure applied to the patient– such as craniosacral manipulation, Brain Curriculum, Craniosacral Therapy, osteopathic manual therapy, etc. and termed in this article as light touch manual therapies (LTMT)– have been effective in treating individuals with TBI (Greenman 1991, Jackman 2007, Arnadottir & Sigurdardottir 2013), and SM (Kozminski & Kozminski 2009) or the general population (Chaibi et al 2011) with headache. Due to the small number of participants and a variety of limitations common to manual therapy research in the studies cited above, this study was designed to further explore the effect of mixed LTMT on self-reported headache, anxiety and other problems suffered by active duty SM.
This pilot study was conducted at an intensive outpatient program (IOP) on a large military installation in the United States from 2011-2012 established to treat active duty SM diagnosed with chronic PTSD. At the IOP, integrative therapies such as medical massage, acupuncture, reiki, and movement therapy were offered together with psychotherapy and psychopharmacology to active duty SM in a six-month full-time therapy program. This pilot study was designed as the first attempt to isolate the effects of one of the medical massage treatments, mixed LTMT, on self-reported headache, anxiety and other problems faced by active duty SM in the IOP program.
It was determined that nine participants would be needed to detect a change in participant outcomes. The study sample consisted of all SM (up to a maximum of twelve) who had been accepted into the IOP during the eight months of recruitment for the pilot study but due to scheduling considerations, had not yet begun to attend IOP activities, and who met all of the other inclusion and exclusion criteria listed in Figure 1. All participants, therefore, had a diagnosis of chronic PTSD, which was a prerequisite for entrance into the IOP. The Defense and Veterans Brain Injury Center’s (DVBIC) 3 Question TBI Screen (Schwab et al 2006) was used to screen for an injury that might have resulted in TBI. Twenty-seven SM were screened and eleven participants were accepted into the study. One participant withdrew prior to the second LTMT session due to work scheduling conflicts and no data from this participant is included in this study. Ten participants completed the study.
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It is common for spontaneous recovery from postconcussive symptoms to occur over the first days to weeks following brain injury (Iverson 2005). Headaches that begin after a brain injury and persist longer than six months are likely to be permanent (Lew et al 2006). To provide a more rigorous test of the LTMT intervention, a self-reported injury to the head at least two years prior was chosen for this study. This also results in increased homogeneity of the participant pool, since individuals with a more recent injury to the head who might experience spontaneous improvement were not included in the sample.
After all data were collected, a retrospective chart review was conducted to confirm a diagnosis of headaches (migraine headache, chronic post-traumatic headache or headache syndromes) or a diagnosis consistent with TBI (including one or more of the following: late effect of intracranial injury, history of TBI, history of concussion) (see Figure 1).
After IRB approval, screening of all SM accepted into the IOP began. If a SM had a positive screen for the pilot study, an appointment was scheduled with the SM to explain the study. Prior to the initial data collection, informed consent was obtained. Participants received two 60-minute mixed LTMT sessions one week apart (see Figure 2). The reason for choosing 60-minute sessions one week apart was to replicate conditions in the IOP. Only two mixed LTMT sessions were given to each participant in order to minimize the delay that pilot study participants might have experienced between acceptance into the IOP and actually beginning full-time participation in the IOP.
Data was collected immediately before and after each mixed LTMT session to capture any immediate effects of the LTMT intervention. Additional data to gauge the durability of the LTMT interventions were collected before each LTMT session and ongoing after the second LTMT session on a weekly basis, until the start of participants’ treatments in the IOP.
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Mixed LTMT protocol
Mixed LTMT was provided according to the same protocol and by the same massage therapist (the primary author) who implemented it at the IOP. Implementation of this technique was ongoing for two years prior with no adverse effects reported. At the beginning of the study, this massage therapist had been certified as a massage therapist for 16 years, was licensed as a massage therapist in Texas, was nationally certified (NCBTMB) and had obtained advanced training in several specific LTMT techniques, including Craniosacral Therapy (Upledger, 3 levels), Brain Curriculum (Chikly, 3 levels), and Visceral Manipulation (Barral, 5 levels).
Each mixed LTMT session was customized for each participant according to the pattern of tension palpated by the massage therapist in the participant’s head and the rest of the body. The primary techniques used during the session included Craniosacral Therapy according to the protocol described by Upledger & Vredevoogd (1996), Brain Curriculum according to the protocols described by Chikly (2004, 2007a, 2007b), and occasional brief petrissage on the neck. All mixed LTMT sessions finished with 2-5 minutes of energy work (Oschman 2000) with the intention of helping the participant to ground and integrate the work. The amount of force exerted by the massage therapist onto the participants varied from very light (5 gm) to moderate (a few hundred gms). During each session, the body parts to which mixed LTMT was administered and the amount of time spent on each body part varied according to the needs of the participants. In all cases at least 80% of the time was spent providing mixed LTMT to the participants’ heads, 5-15% of the time spent providing mixed LTMT the sacral/low back area, with up to 5% of the time spent on the rest of the body.
Immediate data collection
Self-reported data were collected immediately before and after each session in order to assess any effect the mixed LTMT had on headache or anxiety. Headache was measured by asking “On a scale of 0 (no headache) to 10 (most severe headache that you have experienced), how would you rank the intensity of your headache?” If a participant did not have a headache, headache intensity was scored as zero. Similarly, anxiety was measured by asking the question “On a scale of 0 (not at all anxious) to 10 (extremely anxious), how would you rank the intensity of your anxiety?” If a participant reported no anxiety, anxiety intensity was scored as zero. Anxiety was also evaluated using the validated Anxiety Neuro-QoL Bank v1.0 instrument available from the Assessment Center (www.assessmentcenter.net).
All available validated instruments measuring headache, such as the Migraine Disability Assessment Test (Stewart et al 2001) and the Headache Impact Test – 6 (Kosinski et al 2003) ask the participant to reflect on their symptoms over the preceding seven or more days. For example, in a study using classical testing theory versus Item Response Theory to assess fatigue in seven-day or four-week recall periods, Lai et al (2009), suggests that participants use a much shorter time frame of recall, ‘today’, to answer questions requesting a recall of seven days or more. Similarly, Bennett et al (2012) reported that recall of symptoms and impacts over seven day and daily diary scores were equivalent in patients with chronic obstructive pulmonary disease. Thus, in an attempt to gather valuable information about changes in major symptoms, such as anxiety and headache, over the course of a LTMT session, these questions were included.
Durable data collection
Four different instruments, the Patient-Reported Outcomes Measurement Information System (PROMIS; www.nihpromis.org), the Quality of Life in Neurological Diseases (Neuro-QoL; www.neuroqol.org), the PTSD Checklist (PCL), and the Measure Yourself Medical Outcome Profile 2 (MYMOP2), were used to collect self-reported data to determine if mixed LTMT provided relief that lasted for days or weeks. The original intent had been to collect data ongoing at weekly intervals for at least one month or more to determine if effects from the LTMT sessions lasted this length of time, and also to determine if the onset of some effects might have been delayed. For example, the developer of Brain Curriculum has indicated that in many individuals there may be a delay of up to two weeks following administration of the technique before the onset of effects (B Chikly, personal communication February 2010). Prior to the study and during initial trials, SM scheduling would have allowed for ongoing data collection most of the time, but because SM began to be processed into the IOP more quickly, most participants were no longer available for extended data collection. Thus, the number of days between intake (pre) data collection and post data collection ranged from 11 to 15 days.
Data were collected using the PROMIS and Neuro-QoL libraries available from the Assessment Center. PROMIS and Neuro-QOL are comprised of sets of questions called item banks, which assess the health-related quality of life of adults and children, especially those with neurological disorders. Each item bank tests a unique domain such as anxiety, fatigue, satisfaction with social roles and activities, pain interference, etc. For example, the Pain Interference PROMIS Bank v1.0 is designed to measure the negative impact or interference that pain has on the lives of people who experience chronic pain (Amtmann et al 2010). A significant decrease in scores for Pain Interference indicates that participants were not as negatively impacted by pain at the end of the study compared with before the study. Questions in the Pain Interference item bank included, “In the past seven days, how much did pain interfere with your day to day activities?” and “In the past seven days, how much did pain interfere with your ability to participate in social activities?” Pain Interference measurements were calculated using a Likert scale, with the following possible responses: 1-Not at all; 2-A little bit; 3-Somewhat; 4-Quite a bit; 5-Very much. For this study, both PROMIS and Neuro-QOL surveys were presented using the Computerized Adaptive Test feature based on Item Response Theory.
The PTSD Checklist (PCL) was developed and validated as a screening test to identify individuals with PTSD (Weathers et al 1993; McDonald & Calhoun 2010). It has moved into common use as a way for individuals to self-report symptoms of PTSD, and for providers to track PTSD symptoms in response to treatment (Berlant & Van Kammen 2002; Taylor et al 2008). Several versions of the PCL are available and the one used in this study is the military version (PCL-M) (Monson et al 2008) in which the questions reference stressful military events. The PCL-M is scored on a five-point scale ranging from 1 – “Not at All” to 5 – “Extremely.” The measure is divided into three subscales (consistent with DSM IV criteria for PTSD diagnosis): Re-experiencing symptoms (items 1-5); Avoidance/Emotional Numbing symptoms (items 6-12); and Hyper-arousal symptoms (items 12-17). The PCL-M score is obtained by summing the results of all 17 questions and can range from 17-85. For each subscale and for the measure as a whole, an overall severity score is obtained by summing scores on all items. The items of the PCL have high diagnostic specificity and sensitivity, and have good to excellent concurrent validity (mean r = .66) with items of the gold standard of PTSD assessment, the Clinician Administered PTSD Scale (Blanchard et al 1996, Forbes et al 2001). According to criteria developed by Hoge et al (2004), the presence of one re-experiencing symptom, three avoidance and or emotional numbing symptoms, and two hyper-arousal symptoms, along with an overall severity score of 50 or above, indicates PTSD. Not surprisingly, PCL-M scores correlate closely with scores related to other tests of mental health functioning rather than to measures of physical symptoms (Lang et al 2012).
Whether the PCL underestimates or overestimates treatment-related change in comparison with Clinician Administered PTSD Scale is unclear (Lang et al 2012). Typically, PCL scores fluctuate from session to session as might be expected with a measure of emotional symptoms in a population diagnosed with PTSD (Forbes et al 2001; Monson et al 2008). Additionally, a transient increase (which may last several weeks) in PTSD symptoms, followed by decreases in PTSD symptoms, is typical of the pattern of change seen in PTSD patients undergoing treatment (Nishith et al 2002, Gilliam et al 2011, Keller et al 2014). A decrease of ten or more points in PCL score indicates a clinically meaningful change (Weathers et al 1993).
Initial (pre) PCL-M scores were gathered during the intake process by the IOP personnel and these data were shared with the authors of this study. The second (post) PCL-M score was gathered by the research team several days after the second LTMT session. The PCL-M intake score was unavailable for one participant so N = 9 in these analyses.
Measure Yourself Medical Outcome Profile 2
To assess changes in the participants’ sense of well-being and in the symptoms and activities that participants deem important, the researchers gathered data using the validated self-reported quality of life instrument MYMOP2 (Paterson 1996). Upon intake into the study and prior to the first LTMT session, participants were instructed to identify the symptom (headaches, back pain, anxiety, depression, etc.) that most bothered them (Symptom 1), a symptom related to the same problem but which was secondary in impact (Symptom 2), an activity made difficult by the problem causing Symptom 1 (performing their job, working out, being with a lot of people, etc.) and their general feeling of well-being. All questions referenced their feelings over the past seven days. For each symptom, activity or sense of wellbeing, the participant was asked to identify a score on a seven-point Likert scale from 0 (as good as it can be) to 6 (as bad as it can be).
The MYMOP2 test is designed so that a change of at least 1 would be considered meaningful or clinically significant (Guyatt et al 1998, and see http://www.measuringimpact.org/s4-mymop2) with a decrease in the score of symptom, activity or wellbeing considered an improvement. Results are presented as the change in score (pre – post) for each variable. In addition to scores for each variable, the change in MYMOP2 profile score is also presented. The MYMOP2 profile score is the average of the summed variable scores for each individual. Mean or median scores for the sample population scores were not calculated since a meaningful aggregate value for a population would require a sample approaching at least 50 individuals (http://www.measuringimpact.org/s4-mymop2).
The statistical packages SPSS and Minitab as well as commands in Microsoft Excel were used to generate descriptive statistics for the data gathered in the pilot study. Comparisons of data were made using the nonparametric Wilcoxon Signed Rank Test (WSRT) because the sample size was too small to assume they were normally distributed. A two-tailed test was used due to not knowing how participants would respond (e.g. headache symptoms worse or improved) and in order to provide a higher threshold for significance. Effect size for each variable was determined by calculating for Cohen’s d (Cohen 1988).
During intake and the preliminary data collection, participants typically seemed agitated, fidgety and hyper-alert as did many of their peers beginning the program at the IOP. During the LTMT sessions, participants appeared to relax with their eyes closed and their breathing falling into a slower steady rhythm. Many appeared to fall asleep for most of the LTMT sessions. Following the post-intervention survey, participants often offered unsolicited remarks that they felt very relaxed and in many cases, that the reduction in symptom intensity was profound. For example, one participant said, “I feel normal and I haven’t felt like a normal person in years.”
WSRT of data collected before (pre) and after (post) each LTMT session indicated that both headache and anxiety were significantly reduced (each p-value < 0.04) with a large effect size (see Figure 3). This indicates that immediate effects from the LTMT sessions included a reduction in head pain and a decrease in anxiety.
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Data collected using the Assessment Center to measure longer-term effects of the LTMT session indicate that Pain Interference was significantly decreased (p = 0.039) with a large effect size in the direction of improvement several days after the second LTMT session (see Figure 3). None of the other comparisons using the Assessment Center yielded significant results in either a positive or negative direction (see Figure 3). Comparisons of 14 out of 15 variables had a large effect size and the pre – post changes in eight of these variables were in the direction of improvement (Anxiety, Depression, Pain Interference, Ability to Participate in Social Roles and Activities, Positive Affect and Wellbeing) or unchanged (Sleep Disturbance, Applied Cognition Executive Functions, and Satisfaction with Social Roles and Activities). The changes pre – post in six variables (Emotional and Behavioral Dyscontrol, Fatigue, Stigma, Applied Cognition General Concerns, and Upper and Lower Extremity Mobility) were not in the desired direction.
Median PCL-M survey scores significantly increased (p = 0.013) (see Figure 3). Changes in PCL-M scores for individuals were (-1, 2, 3, 3, 6, 10, 12, 14, 20). The change in PCL-M was very small (ranging from -1 to 3) for four participants and if the reliable change index of PCL-M scores is bidirectional, this very small change is unlikely to be clinically meaningful. For four other participants, the change in score ranged from 10-20, which may indicate a clinically meaningful change in these participants. The remaining participant’s score increased by 6, which may indicate an increase in PTSD symptoms, but which is not clinically meaningful.
Nine out of ten participants experienced improvement in at least one variable that they considered to be the most affected by their problems (e.g. symptom one, symptom two, wellbeing or an activity). Three participants experienced change in two areas. Only two participants improved in three of the four measures. None of the participants showed improvement on all four measures. Four participants experienced improvements in one or more variables, but no worsening in any variable. One participant experienced worsening in more than one area and no improvements.
This pilot study investigated the effects of mixed LTMT on SM with PTSD and an injury to the head. The results from this pilot study suggest that mixed LTMT are helpful in reducing pain interference, headache and anxiety in the targeted population, as self-reported by participants, and indicates that LTMT may be a non-pharmacological intervention for these problems. Further investigations into mixed LTMT such as Craniosacral Therapy and Brain Curriculum are warranted by these results.
While the resulting sample population (N = 10) was small, it exceeded the minimum of nine participants we had determined was necessary to detect a change in immediate effects on both headache and anxiety. Sample size was limited by scheduling constraints at the IOP. Future studies of durable effects should include a larger sample size.
While it is possible that the diagnoses listed in participants’ medical charts were inaccurate, headache symptoms were confirmed by participants’ responses during data collection. TBI and headaches were relatively common diagnoses among SM being treated at the IOP. Exposure to an injury to the head that could have caused a TBI were reported by the participants during study screening. It was not possible to further confirm diagnoses due to lack of resources for this pilot study.
Due to limitations in personnel, scheduling, and physical space constraints at the IOP, we were unable to include a control group in this pilot study. Thus, our focus was on determining if there was an effect from mixed LTMT comparing data gathered after the intervention (post) as compared with baseline (pre) data. Future studies should control for exposure to the intervention by providing a sham intervention, wait-list control, or an opportunity for the participants to take a nap on the massage table in the presence of the therapist who is not touching the participant. Inclusion of a group where a standardized intervention protocol is provided could yield important information, although in a clinical setting it is likely that Craniosacral Therapy and Brain Curriculum will be customized for each patient as it was in this study. Additional LTMT therapists should be used to control for effects arising from the use of one individual providing the intervention.
Due to limitations in resources and personnel availability, all data used in this study were self-reported. A comprehensive analysis of the advantages and disadvantages of self-reported data is beyond the scope of this article and the reader is directed to a discussion of patient-reported outcomes by Cella et al (2012). Future studies should aim also to collect directly measured data.
Durability of the effect
Personnel and scheduling constraints also impacted the duration of the pilot study, with the final observation collected only four days following the second LTMT session. Anecdotal evidence suggests that the full benefits of these types of LTMT may not manifest for at least two weeks following treatment (B Chikly, personal communication February 2010). In addition, PTSD symptom exacerbation is not uncommon at the beginning of a treatment program (Nishith et al 2002, Gilliam et al 2011, Keller et al 2014), which was the situation for all of the participants in the pilot study, none of whom had yet begun the IOP. It is unknown whether other symptoms, such as headache, might be exacerbated at the beginning of a treatment program. Similarly, data from several variables in the Assessment Center that changed in an undesirable direction may be indicative of symptom exacerbation due to the start of a treatment program. For example, participants may have experienced the full extent of their fatigue upon finally relaxing after having been traumatized in combat situations. Also, participants might have felt more stigmatized when they admitted that their problems were bad enough to cause them to seek help at the IOP. Because of these limitations, the durability of the effects cannot be fully gauged from this pilot study and future studies should include an extended period for data collection to gauge durability. Future studies should also include instruments designed to collect long-term data on headache persistence and other symptoms.
While it cannot be determined in this pilot study by what mechanism mixed LTMT might alleviate headaches or anxiety symptoms or impact how pain affects a person, there is suggestive literature. Several authors have hypothesized that changes in cell shape and cytoskeleton may underlie the effects of cranial manipulation including LTMT (see Chaitow 2005 and Swanson 2013 for reviews) with effects on cell function mediated through mechanotransduction (Chen & Ingber 1999).
The diversity of neuronal cell types and the presence of specialized microdomains within neurons, such as axons, dendrites and dendritic spines (Steward et al 1988), might provide a rich canvas for LTMT-mediated cytoskeletal changes to be expressed in the brain. Several studies have shown that dendritic spines, a postsynaptic structure in some brain neurons, undergo changes in shape and that these shape changes may be correlated with changes in neuronal function such as learning or memory (Crick 1982, Segal 2005). Postsynaptic areas seem to be particularly well designed for regulation via cytoskeletal changes because they are apparently serviced by an active RNA transport system (Davis et al 1987) and may be able to regulate protein synthesis autonomously in the local intracellular environment (Davis et al 1992). Taken together, these findings suggest that transient changes in neuronal shape, perhaps caused by LTMT, may cause long-term changes in the central nervous system, which in turn may affect headache, anxiety or other physiological processes.
To investigate further the effects of mixed LTMT on headache, anxiety and other problems, it would be important to repeat this study in a larger population with appropriate controls. Additional LTMT sessions might help to evaluate the robustness of the effect and explore the dose-response relationship. The durability of the effects would be easier to assess with a longer period of data collection. This information could establish LTMT as an effective non-pharmacological treatment for headache, anxiety, and other problems.
Identifying the substrate/s by which light scalp pressures, a hallmark of LTMT such as Craniosacral Therapy and Brain Curriculum, may affect physiology would be important to optimize clinical treatment. The use of functional medical imaging to observe neuronal metabolism immediately after LTMT could elucidate the mechanism by which LTMT can affect brain tissue in situ and the ways in which LTMT affects neuronal function. Changes in brain connectivity could be revealed by diffusion tensor imaging after LTMT. Alterations in neuronal cytoskeleton after LTMT could be examined in appropriate animal models. Taken together, future studies could point the way towards safe and effective therapies for problems that are inadequately managed by current medical therapies and may also reveal fundamental biological processes active in a variety of systems.
Thank you to the staff of the IOP for sharing the baseline PCL-M data, Allwyn Evans for help with screening, Drs. Matt Hayat and Larry Lesser for help with statistical analyses, and to Drs. Matt Hayat and Edith Walsh for discussions on experimental design early in the development of this study.
The views expressed in this document are those of the authors and do not reflect the official policy of William Beaumont Army Medical Center, the Department of the Army, or the United States Government.
Role of the Funding Source
There was no funding for this study.
Conflict of Interest
The authors declare that there are no conflicts of interest.
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|Sample size||10 participants|
|Age||27-45 years old at time of consent|
|Inclusion criteria||Accepted into IOP, but had not yet received treatment*|
|Positive screen for TBI|
|Self-reported injury to the head at least 2 years prior to start of study|
|Exclusion criteria||Shrapnel or prosthetics in the spine or cranium|
|History of brain surgery|
|Acute systemic infection|
|Previously received Medical Massage (light touch) on scalp|
|Unable to tolerate light to moderate pressure on scalp or body|
|Lactating or pregnant|
|Diagnosis of chronic PTSD||100%|
|Diagnosis of headache||90%|
|Diagnosis of TBI||80%|
|Variable Name||Desirable Direction of Change (Improvement)||Median(IQR)
N = 10
N = 10
|p-value*||Effect size (Cohen’s d)|
|Anxiety 1st massage||Decrease||4.5(5.5)||0.5(2.0)||0.016||1.27|
|Anxiety 2nd massage||Decrease||4.5(4.8)||1.0(3.5)||0.008||1.26|
|Headache 1st massage||Decrease||1.5(4.8)||0.0(0.3)||0.031||0.82|
|Headache 2nd massage||Decrease||2.0(4.0)||0.0(2.0)||0.031||0.84|
|AnxietyNeuro-QoL Bank v1.0||Decrease||1.4(0.8)||1.2(0.9)||0.109||1.19|
|DepressionNeuro-QoL Bank v1.0||Decrease||0.8(0.7)||0.6(0.8)||0.344||1.81|
|Emotional & Behavioral DyscontrolNeuro-QoL Bank v1.0||Decrease||1.6(0.9)||2.0(0.6)||1.000||0.88|
|FatigueNeuro-QoL Bank v1.0||Decrease||0.6(1.3)||0.9(0.9)||0.687||0.84|
|Pain BehaviorPROMIS Bank v1.0||Decrease||1.1(0.5)||1.1(0.5)||0.180||0.52|
|Pain InterferencePROMIS Bank v1.0||Decrease||1.4(0.8)||1.2(1.2)||0.039||1.11|
|Sleep DisturbanceNeuro-QoL SF v1.0||Decrease||2.0(1.1)||2.0(1.2)||0.508||1.31|
|StigmaNeuro-QoL Bank v1.0||Decrease||0.9(1.0)||1.1(0.8)||0.180||0.96|
|Ability to participate in SRANeuro-QoL Bank v1.0||Increase||-1.0(0.3)||-0.9(0.5)||1.000||1.08|
|Applied Cognition Executive FunctionsNeuro-QoL Bank v1.0||Increase||-2.0(0.4)||-2.0(0.3)||0.344||1.12|
|Applied Cognition General ConcernsNeuro-QoL Bank v1.0||Increase||-1.9(0.8)||-2.0(1.0)||1.000||1.55|
|Lower Extremity Function- MobilityNeuro-QoL Bank v1.0||Increase||-0.4(1.4)||-0.9(0.6)||0.180||1.26|
|Positive Affect & WellbeingNeuro-QoL Bank v1.0||Increase||-0.7(1.3)||-0.6(1.1)||0.344||2.00|
|Satisfaction with SRANeuro-QoL Bank v1.0||Increase||-1.0(0.4)||-1.0(0.6)||0.754||1.50|
|Upper Extremity- Fine MotorNeuro-QoL Bank v1.0||Increase||-0.3(1.5)||-0.7(1.4)||0.727||0.95|
CAPTIONS TO FIGURES
Figure 1– Summary of the demographics of the study sample.
* After data collection was completed, it was learned that one participant received one 60-minute session of reiki from a provider at the IOP after they were accepted into the program and before informed consent for this pilot study was obtained.
Figure 2– Timeline of study. Arrow indicates time.
Figure 3– Results.
IQR = Interquartile Range
SRA = Social Roles and Activities.
*Wilcoxon signed rank test (2 tailed), Bold = p < 0.05
** N = 9
***Within a day or two before the final data was collected, one participant learned that they would not be able to participate in the IOP.